Today you are meeting with Pat, a 42-year-old Caucasian woman, here today for a physical examination. Pat wants to join a local health club. It is required by the facility that she provides a physician’s clearance prior to participation in their exercise/weight loss program. Pat’s BMI is calculated at 28 kg/m2. Her blood glucose is 179 mg/dL. Pat has indicated that she has struggled with her weight for over 20 years. She has tried numerous diets and her weight has fluctuated by 100 pounds (between 155 and 255 pounds). Her current weight is 200 pounds and her goal is to lose 60 pounds. Currently, she reports she has been getting really short of breath with minimal activity and she has been told that her blood pressure is elevated. Today her BP is 148/94. What has occurred at the cellular level during the time that Pat accumulated excessive body fat?
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